UZH research contributes to the containment of sexually transmitted infections

(CONNECT) Researchers at the University of Zurich (UZH) have developed a new method for genome sequencing in collaboration with the University of Buenos Aires: Using specially developed molecular probes, they "fished" the bacterial DNA of sexually transmitted diseases from clinical samples, enabling high-resolution genome analysis, according to a UZH report. "The new method helps us to understand how sexually transmitted diseases spread and adapt," says Helena Seth-Smith from the UZH Institute of Medical Microbiology.

Such genetic information is important for the effective treatment and containment of sexually transmitted infections (STIs). They provide information on how the bacteria responsible for this are related to each other, how they are transmitted and how resistant they are to antibiotics.

Until now, research into the pathogens has been difficult. They cannot usually be cultivated in the laboratory. In addition, clinical samples contain vast amounts of human DNA, which makes the genome sequencing of bacterial STIs very difficult. Using their new method, the researchers in Argentina have also discovered a previously unknown strain of chlamydia. It was found in rectal samples from men.

"The findings underline the dynamic nature of the transmission and development pathways of STIs," says first author Karina Büttner. "With these tools, we can better support public health efforts to control and prevent sexually transmitted infections." ce/mm